{"product_id":"new-product-566210","title":"ATRX Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by ATRX (ATRX, chromatin remodeler) contains an ATPase\/helicase domain, and thus it belongs to the SWI\/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in ATRX are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.\u003c\/p\u003e\n\u003cp\u003eThe ATRX Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of ATRX protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eThe ATRX protein plays a crucial role in chromatin remodeling and maintenance of genome stability. It is involved in various cellular processes, including DNA repair, telomere maintenance, and transcriptional regulation. Dysregulation of ATRX has been implicated in several human diseases, including cancer and neurodevelopmental disorders.\u003cbr\u003e\u003cbr\u003eThe ATRX Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes endogenous levels of ATRX protein in a wide range of species, making it suitable for use in diverse research settings.\u003cbr\u003e\u003cbr\u003eWith its high sensitivity and specificity, this antibody enables accurate and reliable detection of ATRX protein expression, facilitating in-depth investigations into its functional roles and molecular mechanisms. Its robust performance and versatility make it an indispensable tool for researchers studying chromatin remodeling, genome stability, and related fields.\u003cbr\u003e\u003cbr\u003eThe ATRX Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and consistent results. It has been rigorously validated to ensure batch-to-batch consistency and reproducibility, guaranteeing reliable and reproducible data.\u003cbr\u003e\u003cbr\u003eIn summary, the ATRX Polyclonal Antibody is a valuable research tool that offers exceptional sensitivity, specificity, and versatility for the detection and analysis of ATRX protein expression. Its high-quality performance and reliable results make it an essential component of any research project focused on chromatin remodeling, genome stability, and associated areas of study.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47540983103768,"sku":"BT-AP00758","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_a30d5900-779a-448d-9b55-c9eb5d48417f.png?v=1705611559","url":"https:\/\/danabiosci.com\/products\/new-product-566210","provider":"Dana Bioscience","version":"1.0","type":"link"}