{"product_id":"new-product-386680","title":"HSF1 (phospho Ser303) Rabbit Polyclonal Antibody","description":"\u003cp\u003eHSF1 (phospho Ser303) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\u003cdiv class=\"item item1\"\u003e\n\u003ch4 class=\"tit clearfix tabs\"\u003e\u003cspan class=\"fz20 fl tran300 active\"\u003eOverview\u003c\/span\u003e\u003c\/h4\u003e\n\u003cdiv class=\"cont fz16 pageStyle\"\u003e\n\u003cdiv id=\"tabs-container\" class=\"container1 swiper-container-horizontal swiper-container-autoheight\"\u003e\n\u003cdiv class=\"swiper-wrapper\"\u003e\n\u003cdiv class=\"swiper-slide pageStyle fz16 swiper-no-swiping swiper-slide-active\"\u003e\n\u003ctable class=\"table2\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"208px\" class=\"fz18\"\u003eProduct name:\u003c\/td\u003e\n\u003ctd\u003eHSF1 (phospho Ser303) rabbit pAb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eAlternative Names:\u003c\/td\u003e\n\u003ctd\u003eHSF1; HSTF1; Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1; HSTF 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eApplications:\u003c\/td\u003e\n\u003ctd\u003eWB;IHC;IF;ELISA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eRecommended Dilutions:\u003c\/td\u003e\n\u003ctd\u003eWestern Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eImmunogen:\u003c\/td\u003e\n\u003ctd\u003eThe antiserum was produced against synthesized peptide derived from human HSF1 around the phosphorylation site of Ser303. AA range:270-319\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eStorage:\u003c\/td\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eStorage:\u003c\/td\u003e\n\u003ctd\u003e-20°C\/1 year\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eClonality:\u003c\/td\u003e\n\u003ctd\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eIsotype:\u003c\/td\u003e\n\u003ctd\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eConcentration:\u003c\/td\u003e\n\u003ctd\u003e1 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eObserved Band:\u003c\/td\u003e\n\u003ctd\u003e82kD\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eGeneID（Human）:\u003c\/td\u003e\n\u003ctd\u003e3297\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eHuman Swiss-Prot No:\u003c\/td\u003e\n\u003ctd\u003eQ00613\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eCellular localization:\u003c\/td\u003e\n\u003ctd\u003eNucleus . Cytoplasm . Nucleus, nucleoplasm . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . The monomeric form is cytoplasmic in unstressed cells (PubMed:8455624, PubMed:26159920). Predominantly nuclear protein in both unstressed and heat shocked cells (PubMed:10413683, PubMed:10359787). Translocates in the nucleus upon heat shock (PubMed:8455624). Nucleocytoplasmic shuttling protein (PubMed:26159920). Colocalizes with IER5 in the nucleus (PubMed:27354066). Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:8455624, PubMed:26159920). Localizes in subnuclear granules called nuclear stress bodies (nSBs) upon heat shock (PubMed:11447121, PubMed:1151455\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eBackground:\u003c\/td\u003e\n\u003ctd\u003eheat shock transcription factor 1(HSF1) Homo sapiens The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phsphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Aug 2016],\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"fz18\"\u003eSpecies Reactivity:\u003c\/td\u003e\n\u003ctd\u003eHuman;Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"item item5\"\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca class=\"scaleimg\"\u003e\n\u003cdiv class=\"pic\"\u003e\u003cimg class=\"tran500\" alt=\"\" src=\"https:\/\/www.elkbiotech.com\/upload\/image\/Antibodies\/pAb\/ES5778-c-1.jpg\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"text fz16\"\u003eWestern Blot analysis of MCF7+TNF cells using Phospho-HSF1 (S303) Polyclonal Antibody diluted at 1:1000\u003c\/div\u003e\n\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca class=\"scaleimg\"\u003e\n\u003cdiv class=\"pic\"\u003e\u003cimg class=\"tran500\" alt=\"\" src=\"https:\/\/www.elkbiotech.com\/upload\/image\/Antibodies\/pAb\/ES5778-c-2.jpg\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"text fz16\"\u003eImmunohistochemistry analysis of paraffin-embedded human breast carcinoma, using HSF1 (Phospho-Ser303) Antibody. The picture on the right is blocked with the phospho peptide.\u003c\/div\u003e\n\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca class=\"scaleimg\"\u003e\n\u003cdiv class=\"pic\"\u003e\u003cimg class=\"tran500\" alt=\"\" src=\"https:\/\/www.elkbiotech.com\/upload\/image\/Antibodies\/pAb\/ES5778-c-3.jpg\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"text fz16\"\u003eWestern blot analysis of lysates from MCF7 cells treated with TNF-alpha 20ng\/ml 30', using HSF1 (Phospho-Ser303) Antibody. The lane on the left is blocked with the phospho peptide.\u003c\/div\u003e\n\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ELK Biotechnology","offers":[{"title":"100ul","offer_id":47446684008728,"sku":"ES5778","price":248.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/ELK_94bafda2-d9fb-44ac-b957-d4a92ec4a18b.jpg?v=1704320436","url":"https:\/\/danabiosci.com\/products\/new-product-386680","provider":"Dana Bioscience","version":"1.0","type":"link"}