{"product_id":"new-product-340370","title":"A20 (A-12)","description":"\u003cp\u003eA20 Antibody (A-12) is a high quality monoclonal A20 antibody (also designated TNFAIP3 antibody, or TNF a induced protein 3 antibody). A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor k B (NFkB) gene expression. By inhibiting NFkB activation, A20 plays a critical role in terminating NFkB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFkB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) g protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.\u003c\/p\u003e","brand":"Dbiosys","offers":[{"title":"1ml \/ Rabbit","offer_id":47433499902232,"sku":"Mob598","price":535.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/A20-A12.jpg?v=1704033964","url":"https:\/\/danabiosci.com\/products\/new-product-340370","provider":"Dana Bioscience","version":"1.0","type":"link"}