{"product_id":"new-product-328988","title":"Human pro-BDNF Protein","description":"\u003cstrong\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/strong\u003e\n\u003cdiv class=\"product-section\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"large-10 col pb-0 mb-0\"\u003e\n\u003cdiv class=\"large-8 col pb-0 mb-0\"\u003e\n\u003ch5 class=\"uppercase mt\"\u003ePRODUCT DATA\u003c\/h5\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"panel entry-content\"\u003e\n\u003ctable class=\"woocommerce-product-attributes shop_attributes\"\u003e\n\u003ctbody\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_target\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eTARGET\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003e\u003ca rel=\"tag\" href=\"https:\/\/www.dimabio.com\/target\/pro-bdnf\"\u003epro-BDNF\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_synonyms\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eSYNONYMS\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eBrain-Derived Neurotrophic Factor;BDNF;Abrineurin\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_description\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eDESCRIPTION\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eRecombinant Human Pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247(R125A,R127A,R128A) is expressed.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_delivery\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eDELIVERY\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eIn Stock\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_uniprot-id\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eUNIPROT ID\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eP23560\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_expression-host\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eEXPRESSION HOST\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eE.coli\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_tag\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eTAG\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_molecular-characterization\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eMOLECULAR CHARACTERIZATION\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eNot available\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_molecular-weight\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eMOLECULAR WEIGHT\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003e25.6 KDa\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_purity\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003ePURITY\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eGreater than 95% as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_formulation-reconstitution\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eFORMULATION \u0026amp; RECONSTITUTION\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_storage-shipping\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eSTORAGE \u0026amp; SHIPPING\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eStore at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_background\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eBACKGROUND\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eThe precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_usage\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eUSAGE\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eResearch use only\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-section\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"large-10 col pb-0 mb-0\"\u003e\n\u003cdiv class=\"large-8 col pb-0 mb-0\"\u003e\n\u003ch5 class=\"uppercase mt\"\u003eIMAGES\u003c\/h5\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"panel entry-content\"\u003e\n\u003cp\u003e\u003cimg loading=\"eager\" sizes=\"(max-width: 247px) 100vw, 247px\" data-lazy-loaded=\"1\" srcset=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/proteins\/sp\/PME30058-C077-P23560-SDS-PAGE-0-247x400.jpg 247w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/proteins\/sp\/PME30058-C077-P23560-SDS-PAGE-0-100x162.jpg 100w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/proteins\/sp\/PME30058-C077-P23560-SDS-PAGE-0-64x104.jpg 64w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/proteins\/sp\/PME30058-C077-P23560-SDS-PAGE-0.jpg 310w\" class=\"alignnone size-medium wp-image-9851 jetpack-lazy-image jetpack-lazy-image--handled\" height=\"400\" width=\"247\" alt=\"sp-PME30058 C077 P23560 SDS PAGE 0\" src=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/proteins\/sp\/PME30058-C077-P23560-SDS-PAGE-0-247x400.jpg\" decoding=\"async\" fetchpriority=\"high\"\u003e\u003c\/p\u003e\n\u003cp\u003eFigure 1. Greater than 95% as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Dima Biotech","offers":[{"title":"50ug \/ pro-BDNF \/ P23560","offer_id":47431972684056,"sku":"PME30058","price":360.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/Dimabio_c85d102b-ef26-453f-ba1b-05a993dbea53.png?v=1703982607","url":"https:\/\/danabiosci.com\/products\/new-product-328988","provider":"Dana Bioscience","version":"1.0","type":"link"}