{"product_id":"new-product-326497","title":"Anti-CD142 antibody(DMC463), IgG1 Chimeric mAb","description":"\u003cdiv data-mce-fragment=\"1\" class=\"product-section\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"row\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"large-10 col pb-0 mb-0\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"panel entry-content\"\u003e\n\u003cp\u003e\u003cstrong\u003ePRODUCT DATA \u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable data-mce-fragment=\"1\" class=\"woocommerce-product-attributes shop_attributes\"\u003e\n\u003ctbody data-mce-fragment=\"1\"\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_target\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eTARGET\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003ca data-mce-fragment=\"1\" rel=\"tag\" href=\"https:\/\/www.dimabio.com\/target\/cd142\" data-mce-href=\"https:\/\/www.dimabio.com\/target\/cd142\"\u003eCD142\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_synonyms\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eSYNONYMS\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTF; Coagulation factor III; F3\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_host-species\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eHOST SPECIES\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eRabbit\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_description\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eDESCRIPTION\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAnti-CD142 antibody(DMC463); IgG1 Chimeric mAb\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_delivery\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eDELIVERY\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eIn Stock\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_uniprot-id\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eUNIPROT ID\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eP13726\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_igg-type\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eIGG TYPE\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eRabbit:Human Fc chimeric IgG1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_clonality\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eCLONALITY\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eMonoclonal\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_reactivity\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eREACTIVITY\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eHuman\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_applications\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eAPPLICATIONS\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eFlow Cyt\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_recommended-dilutions\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eRECOMMENDED DILUTIONS\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eFlow Cyt 1:100\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_purification\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003ePURIFICATION\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003ePurified from cell culture supernatant by affinity chromatography\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_formulation-reconstitution\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eFORMULATION \u0026amp; RECONSTITUTION\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eLyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_storage-shipping\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eSTORAGE \u0026amp; SHIPPING\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eStore at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_background\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eBACKGROUND\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThis gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades; and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades; which circulate as nonfunctional precursors; this factor is a potent initiator that is fully functional when expressed on cell surfaces; for example; on monocytes. There are 3 distinct domains of this factor: extracellular; transmembrane; and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli; and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq; Aug 2020]\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_usage\"\u003e\n\u003cth data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__label\"\u003eUSAGE\u003c\/th\u003e\n\u003ctd data-mce-fragment=\"1\" class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eResearch use only\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"product-section\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"row\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"large-10 col pb-0 mb-0\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"large-8 col pb-0 mb-0\"\u003e\n\u003ch5 data-mce-fragment=\"1\" class=\"uppercase mt\"\u003eIMAGES\u003c\/h5\u003e\n\u003c\/div\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"panel entry-content\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cimg data-mce-fragment=\"1\" loading=\"eager\" sizes=\"(max-width: 399px) 100vw, 399px\" data-lazy-loaded=\"1\" srcset=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/antibody\/DMC100463-CD142-Fig.1-FC-1-399x400.jpg 399w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/antibody\/DMC100463-CD142-Fig.1-FC-1-100x100.jpg 100w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/antibody\/DMC100463-CD142-Fig.1-FC-1-64x64.jpg 64w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/antibody\/DMC100463-CD142-Fig.1-FC-1-280x280.jpg 280w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/antibody\/DMC100463-CD142-Fig.1-FC-1.jpg 591w\" class=\"alignnone size-medium wp-image-7919 jetpack-lazy-image jetpack-lazy-image--handled\" height=\"400\" width=\"399\" alt=\"antibody-DMC100463 CD142 Fig.1 FC 1\" src=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/antibody\/DMC100463-CD142-Fig.1-FC-1-399x400.jpg\" decoding=\"async\" fetchpriority=\"high\" data-mce-src=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/antibody\/DMC100463-CD142-Fig.1-FC-1-399x400.jpg\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eFigure 1. Flow cytometry analysis with Anti-CD142 (DMC463) on Expi293 cells transfected with human CD142 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Dima Biotech","offers":[{"title":"100 μg \/ Flow Cyt 1:100 \/ Monoclonal","offer_id":47431107969304,"sku":"DMC100463","price":438.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/Dimabio_0dc2489d-49eb-4af3-aeb1-4e87a75d23a3.png?v=1703966428","url":"https:\/\/danabiosci.com\/products\/new-product-326497","provider":"Dana Bioscience","version":"1.0","type":"link"}