{"product_id":"new-product-326388","title":"Human CLDN18.2 full length protein-VLP","description":"\u003cdiv class=\"product-section\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"large-10 col pb-0 mb-0\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"large-8 col pb-0 mb-0\" data-mce-fragment=\"1\"\u003e\n\u003ch5 class=\"uppercase mt\" data-mce-fragment=\"1\"\u003ePRODUCT DATA\u003c\/h5\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"panel entry-content\" data-mce-fragment=\"1\"\u003e\n\u003ctable class=\"woocommerce-product-attributes shop_attributes\" data-mce-fragment=\"1\"\u003e\n\u003ctbody data-mce-fragment=\"1\"\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_target\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eTARGET\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003ca href=\"https:\/\/www.dimabio.com\/target\/cldn18-2\" rel=\"tag\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.dimabio.com\/target\/cldn18-2\"\u003eCLDN18.2\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_synonyms\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eSYNONYMS\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eClaudin 18.2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_description\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eDESCRIPTION\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eHuman Full length Claudin 18.2 Protein-VLP\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_delivery\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eDELIVERY\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eIn Stock\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_uniprot-id\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eUNIPROT ID\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eP56856\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_expression-host\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eEXPRESSION HOST\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eHEK293\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_protein-families\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003ePROTEIN FAMILIES\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTransmembrane\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_protein-pathways\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003ePROTEIN PATHWAYS\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_molecular-weight\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eMOLECULAR WEIGHT\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe Human CLDN18.2 Protein has a predicted MW of 29 kDa.Due to PTM, the actual MW on SDS-PAGE gel is around 50kDa.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_formulation-reconstitution\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eFORMULATION \u0026amp; RECONSTITUTION\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eLyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_storage-shipping\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eSTORAGE \u0026amp; SHIPPING\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eStore at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_background\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eBACKGROUND\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe protein encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC\/MAPK\/AP-1 (protein kinase C\/mitogen-activated protein kinase\/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_usage\" data-mce-fragment=\"1\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\" data-mce-fragment=\"1\"\u003eUSAGE\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eResearch use only\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-section\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"large-10 col pb-0 mb-0\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"large-8 col pb-0 mb-0\" data-mce-fragment=\"1\"\u003e\n\u003ch5 class=\"uppercase mt\" data-mce-fragment=\"1\"\u003eIMAGES\u003c\/h5\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"panel entry-content\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cimg decoding=\"async\" src=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1-499x400.jpg\" alt=\"elisa-FLP100006 CLDN18.2 Fig.1 Elisa 1\" width=\"499\" height=\"400\" class=\"alignnone size-medium wp-image-8030 jetpack-lazy-image jetpack-lazy-image--handled\" srcset=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1-499x400.jpg 499w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1-100x80.jpg 100w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1-64x51.jpg 64w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1-999x800.jpg 999w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1-768x615.jpg 768w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1.jpg 1217w\" data-lazy-loaded=\"1\" sizes=\"(max-width: 499px) 100vw, 499px\" loading=\"eager\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/elisa\/FLP100006-CLDN18.2-Fig.1-Elisa-1-499x400.jpg\" fetchpriority=\"high\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eFigure1. ELISA plates were pre-coated with 0.5ug\/per well purified human CLDN18.2 VLP. Serial diluted Anti-CLDN18.2 monoclonal antibody (Zolbetuximab biosililar; IMAB362) solutions were added, washed, and incubated with secondary antibody before ELISA reading. From above data, the EC50 for IMAB362 binding with CLDN18.2 VLP is 15.37ng\/ml.\u003cbr data-mce-fragment=\"1\"\u003e\u003cimg decoding=\"async\" src=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/fc\/FLP100006-CLDN18.2-Fig.2-FC-1-800x216.jpg\" alt=\"fc-FLP100006 CLDN18.2 Fig.2 FC 1\" width=\"800\" height=\"216\" class=\"alignnone size-medium wp-image-8069 jetpack-lazy-image jetpack-lazy-image--handled\" srcset=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/fc\/FLP100006-CLDN18.2-Fig.2-FC-1-800x216.jpg 800w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/fc\/FLP100006-CLDN18.2-Fig.2-FC-1-100x27.jpg 100w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/fc\/FLP100006-CLDN18.2-Fig.2-FC-1-64x17.jpg 64w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/fc\/FLP100006-CLDN18.2-Fig.2-FC-1-768x208.jpg 768w, https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/fc\/FLP100006-CLDN18.2-Fig.2-FC-1.jpg 1268w\" data-lazy-loaded=\"1\" sizes=\"(max-width: 800px) 100vw, 800px\" loading=\"eager\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/www.dimabio.com\/wp-content\/uploads\/products\/flp\/fc\/FLP100006-CLDN18.2-Fig.2-FC-1-800x216.jpg\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eFigure2. FACS analysis of CLDN18.2 VLP\u003cbr data-mce-fragment=\"1\"\u003eA. Negative Control 1: CLDN18.2 VLP were stained only with Goat anti-human IgG Fc-PE secondary antibody.\u003cbr data-mce-fragment=\"1\"\u003eB. Negative Control 2: Control VLP were stained with anti-CLDN18.2 antibody (Zolbetuximab biosimilar; IMAB362) at 1μg\/mL, followed by Goat anti-human IgG Fc-PE secondary antibody.\u003cbr data-mce-fragment=\"1\"\u003eC. Negative Control 3: CLDN18.2 VLP were stained with anti-BCMA antibody（an irrelevant antibody）at 1μg\/mL, followed by Goat anti-human IgG Fc-PE secondary antibody.\u003cbr data-mce-fragment=\"1\"\u003eD. CLDN18.2 VLP were stained with anti-CLDN18.2 antibody（Zolbetuximab biosimilar; IMAB362）at 1μg\/mL, followed by Goat anti-human IgG Fc-PE secondary antibody.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Dima Biotech","offers":[{"title":"50μg","offer_id":47431089717528,"sku":"FLP100006","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/Dimabio_7caddf96-3afa-4666-88eb-1e89a33a62a9.png?v=1703965989","url":"https:\/\/danabiosci.com\/products\/new-product-326388","provider":"Dana Bioscience","version":"1.0","type":"link"}