{"product_id":"new-product-284860","title":"CD3e monoclonal antibody","description":"\u003cp\u003eWhen T cells encounter antigens via the T cell receptor (TCR), information about the quantity and quality of antigens is relayed to the intracellular signal transduction machinery . This activation process depends mainly on CD3 (Cluster of Differentiation 3), a multiunit protein complex that directly associates with the TCR. CD3 is composed of four polypeptides: ζ, γ, ε, and δ. Each of these polypeptides contains at least one immunoreceptor tyrosine-based activation motif (ITAM) . Engagement of the TCR complex with foreign antigens induces tyrosine phosphorylation in the ITAM motifs and phosphorylated ITAMs function as docking sites for signaling molecules such as ZAP-70 and the p85 subunit of PI-3 kinase . TCR ligation also induces a conformational change in CD3ε, such that a proline region is exposed and then associates with the adaptor protein Nck .\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":45810349900056,"sku":"ABCBW12950","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_3f425848-2ae6-440d-8461-4a2105e469b8.png?v=1689762609","url":"https:\/\/danabiosci.com\/products\/new-product-284860","provider":"Dana Bioscience","version":"1.0","type":"link"}