{"product_id":"new-product-284814","title":"Estrogen Receptor alpha monoclonal antibody","description":"\u003cp\u003eEstrogen receptor α (ERα), a member of the steroid receptor superfamily, contains highly conserved DNA binding and ligand binding domains . Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERα regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation at multiple sites provides an important mechanism to regulate ERα activity . Ser104, 106, 118, and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serine residues plays an important role in regulating ERα activity. Ser118 may be the substrate of the transcription regulatory kinase CDK7 . Ser167 may be phosphorylated by p90RSK and Akt . According to the research literature, phosphorylation at Ser167 may confer tamoxifen resistance in breast cancer patients .\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":45810289049880,"sku":"ABCBW12904","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_f9847b78-d59b-42ad-8386-6d90e3f72106.png?v=1689762502","url":"https:\/\/danabiosci.com\/products\/new-product-284814","provider":"Dana Bioscience","version":"1.0","type":"link"}