{"product_id":"new-product-284545","title":"IL-4 Rat monoclonal antibody","description":"\u003cp\u003eIL-4 is produced by T cells, NK T cells, γδ cells, and mast cells. Target cells include B cells, T cells, and macrophages. IL-4 induces the polarization of naïve helper T cells into the TH2 phenotype. IL-4 also promotes B cell proliferation, antibody class switching and the production other TH2 cytokines including IL-5 and IL-9. IL-4 induced TH2 polarization is important in developing humoral immunity against extracellular pathogens and is involved in the development of allergy and asthma. IL-4 binds to two distinct receptors, the Type I receptor and Type II receptor. Type I receptor is a heterodimer consisting of IL-4Rα chain and the common gamma chain, γc. Type II receptor, which is shared with IL-13, is a heterodimer of IL-4Rα and IL-13Rα1. Signaling initiated via Type I receptor results in the activation of Jak1\/Stat6, Jak3 and the PI3K\/Akt pathways. The Type II receptor activates the Jak1\/Stat6 and the Tyk2\/Stat3 pathways.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rat \/ Mouse","offer_id":45809941545240,"sku":"ABCBW12635","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_1b17bdb9-784b-4c24-a168-6d43bd732326.png?v=1689761833","url":"https:\/\/danabiosci.com\/products\/new-product-284545","provider":"Dana Bioscience","version":"1.0","type":"link"}