{"product_id":"new-product-284497","title":"IL-17A monoclonal antibody","description":"\u003cp\u003eIL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders. IL-17A effects appear to be exerted primarily through binding to the IL-17RA. IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1\/2 MAP kinase, PI3K\/Akt, p38, and NF-κB pathways. Phosphorylation of some Jaks and Stats has been observed.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":45809883644184,"sku":"ABCBW12587","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_bbb6bcc4-4707-459b-bb15-d0b0d46b9feb.png?v=1689761714","url":"https:\/\/danabiosci.com\/products\/new-product-284497","provider":"Dana Bioscience","version":"1.0","type":"link"}