{"product_id":"new-product-284385","title":"RAD9A monoclonal antibody","description":"\u003cp\u003eComponent of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C(RFC)clamp loader complex.Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair(LP-BER).The 9-1-1 complex stimulates DNA polymerase beta(POLB)activity by increasing its affinity for the 3´-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds;endonuclease FEN1 cleavage activity on substrates with double,nick,or gap flaps of distinct sequences and lengths;and DNA ligase I(LIG1)on long-patch base excision repair substrates.The 9-1-1 complex is necessary for the recruitment of C12orf32\/RHINO to sites of double-stranded breaks(DSB)occurring during the S phase.RAD9A possesses 3´-\u0026gt;5´ double stranded DNA exonuclease activity.Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Mouse \/ Human,Mouse,Rat,Monkey","offer_id":45809827610904,"sku":"ABCBW12475","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_e4c8f9d9-c08d-4f32-b278-378a24007788.png?v=1689761463","url":"https:\/\/danabiosci.com\/products\/new-product-284385","provider":"Dana Bioscience","version":"1.0","type":"link"}