{"product_id":"new-product-284229","title":"FXR polyclonal antibody","description":"\u003cp\u003eThe farnesoid X receptor (FXR\/NR1H4) is a member of the nuclear hormone receptor superfamily and is a master regulator of bile acid synthesis. FXR\/NR1H4 heterodimerizes with RXR-alpha upon activation by bile acids, which begins a regulatory cascade involving SHP and LRH-1 to control lipid homeostasis. FXR\/NR1H4 has also been shown to be a critical regulator of glucose homeostasis. In addition to directly regulating genes, FXR\/NR1H4 also plays a post transcriptional role in bile acid metabolism by transcribing the RNA-binding protein ZFP36L1, which in turn downregulates the key enzyme Cyp7a1. Mutations in human FXR\/NR1H4 have been shown to cause cholestasis and liver disease in neonatal patients. FXR\/NR1H4 can also control Lgr5+ intestinal stem cell proliferation and its upregulation has been shown to inhibit colorectal cancer progression. Agonists against FXR\/NR1H4 are being evaluated for various liver diseases and diabetes.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":45809763123480,"sku":"ABCBW12319","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_84749ece-44e2-48b8-9bd0-fc7fbf9c8233.png?v=1689761069","url":"https:\/\/danabiosci.com\/products\/new-product-284229","provider":"Dana Bioscience","version":"1.0","type":"link"}