{"product_id":"new-product-284119","title":"Notch 1 Rabbit monoclonal antibody","description":"\u003cp\u003eNotch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain. Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse","offer_id":45809721409816,"sku":"ABCBW12209","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_41d20be7-a51d-4d98-bd49-c83bad858417.png?v=1689760807","url":"https:\/\/danabiosci.com\/products\/new-product-284119","provider":"Dana Bioscience","version":"1.0","type":"link"}