{"product_id":"new-product-284095","title":"IGF-2R Rabbit monoclonal antibody","description":"\u003cp\u003eThe mannose 6-phosphate\/insulin-like growth factor II receptor, IGF-IIR (also designated M6P\/IGF2R), is an ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGFβ1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore,IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45809714200856,"sku":"ABCBW12185","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_b5e07d2c-5a6e-4d2d-aaa4-85330b12ca93.png?v=1689760758","url":"https:\/\/danabiosci.com\/products\/new-product-284095","provider":"Dana Bioscience","version":"1.0","type":"link"}