{"product_id":"new-product-283972","title":"PKCα (Phospho-T638) polyclonal antibody","description":"Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine\/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms (α, βI, βII, γ, δ, ε, ζ, η, θ, λ\/ι, μ and ν). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC δ and ε are independent of Ca\u003csup\u003e2+\u003c\/sup\u003e. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":45809634279704,"sku":"ABCBW12062","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_3a608d40-8840-4cf2-bd8e-a1a69c6c644d.png?v=1689760476","url":"https:\/\/danabiosci.com\/products\/new-product-283972","provider":"Dana Bioscience","version":"1.0","type":"link"}