{"product_id":"new-product-283846","title":"PHF3 (D2033) polyclonal antibody","description":"\u003cp\u003ePHF3 (PHD finger protein 3) is a 2039 amino acid ubiquitously expressed protein that is phosphorylated upon DNA damage by either ATM or ATR. PHF3 contains a PHD finger motif, a proline-rich region, a TFIIS domain and two bipartite nuclear localization signals. Since these motifs are frequently found in proteins involved in transcription, PHF3 may function as a transcription factor. Expression of PHF3 is significantly reduced in anaplastic astrocytomas, glioblastomas and glioblastoma cell lines, suggesting that PHF3 plays a role as a tumor suppressor. Antibodies against PHF3 are present in some patients afflicted with glioblastoma multiforme and presence of the , correlates to significantly better survival rates. There are two isoforms of PHF3 that are produced as a result of alternative splicing events.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse","offer_id":45809586045208,"sku":"ABCBW11936","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_c071d9d6-9c99-457e-b6a9-ad1f060f4d4c.png?v=1689760163","url":"https:\/\/danabiosci.com\/products\/new-product-283846","provider":"Dana Bioscience","version":"1.0","type":"link"}