{"product_id":"new-product-283291","title":"NLRC3 polyclonal antibody","description":"\u003cp\u003eNegative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING\/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) . May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination. Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1\/PIK3R2) and disrupting the association between PIK3R1\/PIK3R2 and the catalytic subunit p110 (PIK3CA\/PIK3CB\/PIK3CD) and reducing PIK3R1\/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse","offer_id":45809413488920,"sku":"ABCBW11381","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_d81efb39-49ae-45e8-8766-b1efbb0a703b.png?v=1689758831","url":"https:\/\/danabiosci.com\/products\/new-product-283291","provider":"Dana Bioscience","version":"1.0","type":"link"}