{"product_id":"new-product-283253","title":"Na+\/K+-ATPase polyclonal antibody","description":"The ubiquitously expressed sodium\/potassium-ATPase (Na\u003csup\u003e+\u003c\/sup\u003e\/K\u003csup\u003e+\u003c\/sup\u003e-ATPase) exists as an oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na\u003csup\u003e+\u003c\/sup\u003e ions and two K\u003csup\u003e+\u003c\/sup\u003e ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na\u003csup\u003e+\u003c\/sup\u003e\/K\u003csup\u003e+\u003c\/sup\u003e-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, α, β and γ, comprise the Na\u003csup\u003e+\u003c\/sup\u003e\/K\u003csup\u003e+\u003c\/sup\u003e-ATPase oligomer. The α subunit contains the binding sites for ATP and the cations; the glycosylated β subunit ensures correct folding and membrane insertion of the α subunits. The small γ subunit co-localizes with the α subunit in nephron segments, where it increases the affinity of Na\u003csup\u003e+\u003c\/sup\u003e\/K\u003csup\u003e+\u003c\/sup\u003e-ATPase for ATP. The β subunit, but not the γ subunit, is essential for normal activity of Na\u003csup\u003e+\u003c\/sup\u003e\/K\u003csup\u003e+\u003c\/sup\u003e-ATPase.","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":45809397563672,"sku":"ABCBW11343","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_cc647bb3-d9b2-46d8-b13c-0613b60f0df4.png?v=1689758733","url":"https:\/\/danabiosci.com\/products\/new-product-283253","provider":"Dana Bioscience","version":"1.0","type":"link"}