{"product_id":"new-product-281913","title":"HSD11B1 polyclonal antibody","description":"\u003cp\u003eGlucocorticoid hormone action in target tissues is modulated by 11b-hydroxysteroid dehydrogenase (11b-HSD), which catalyzes the interconversion of hormonally active C11-hydroxylated corticosteroids (cortisol, corticosterone) and their inactive C11-keto metabolites (cortisone, 11-dehydrocorticosterone). At least two isoforms of 11b-HSD exist: a low-affinity NADP-dependent dehydrogenase\/oxoreductase (11b-HSD1) and a high-affinity NAD-dependent dehydrogenase (11b-HSD2). The glycosylated 11b-HSD1 protein activates cortisol from cortisone, which is widely expressed in mammals, and is most highly expressed in the liver. 11b-HSD1 may play a role in glucose homeostasis and pathogenesis of a number of disorders including insulin resistance and obesity.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Mouse","offer_id":45809119854872,"sku":"ABCBW10003","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_0f6192e2-12ef-436e-862f-99a14808a6ae.png?v=1689755524","url":"https:\/\/danabiosci.com\/products\/new-product-281913","provider":"Dana Bioscience","version":"1.0","type":"link"}