{"product_id":"new-product-281689","title":"CLIC1 polyclonal antibody","description":"\u003cp\u003eChloride intracellular channel 1 (CLIC1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. CLIC1 is a monomeric protein that\u003cbr\u003e\ncontains a redox-active site similar to glutaredoxin; it functions as a anionselective channel. CLIC1 forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment\u003cbr\u003e\nprevents this from occurring. Insulin concentration also plays a role in CLIC1 regulation, and the hormone may cause a subnuclear relocalization of CLIC1. CLIC1 is associated with macrophage activation; a downregulation of CLIC1 function prevents TNFα release induced by β-Amyloid protein (A-β) stimulation. This suggests a role for CLIC1 in several neurodegenerative processes, such as Alzheimer’s disease, a syndrome characterized by an\u003cbr\u003e\naccumulation of A-β.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45809045274904,"sku":"ABCBW09779","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_a049933f-d7b9-4a67-9b82-8533f24a6a28.png?v=1689754997","url":"https:\/\/danabiosci.com\/products\/new-product-281689","provider":"Dana Bioscience","version":"1.0","type":"link"}