{"product_id":"new-product-279769","title":"NFKBIZ polyclonal antibody","description":"\u003cp\u003eInvolved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1\/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1\/p50 has transcriptional activation activity and, together with NFKB1\/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR\/IL-1 receptor signaling. May promote apoptosis.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45808484647192,"sku":"ABCBW07859","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_68bf19b1-1594-48b1-b0ca-d36a01d43c47.png?v=1689750373","url":"https:\/\/danabiosci.com\/products\/new-product-279769","provider":"Dana Bioscience","version":"1.0","type":"link"}