{"product_id":"new-product-278307","title":"NDRG1 polyclonal antibody","description":"\u003cp\u003eN-myc downstream-regulated gene 1 (NDRG1), also termed Cap43, Drg1, RTP\/rit42, and Proxy-1, is a member of the NDRG family, which is composed of four members (NDRG1-4) that function in growth, differentiation, and cell survival. NDRG1 is ubiquitously expressed and highly responsive to a variety of stress signals including DNA damage , hypoxia , and elevated levels of nickel and calcium . Expression of NDRG1 is elevated in N-myc defective mice and is negatively regulated by N- and c-myc . During DNA damage, NDRG1 is induced in a p53-dependent fashion and is necessary for p53-mediated apoptosis . Research studies have shown that NDRG1 may also play a role in cancer progression by promoting differentiation, inhibiting growth, and modulating metastasis and angiogenesis . Nonsense mutation of the NDRG1 gene has been shown to cause hereditary motor and sensory neuropathy-Lom (HMSNL), which is supported by studies demonstrating the role of NDRG1 in maintaining myelin sheaths and axonal survival . NDRG1 is up-regulated during mast cell maturation and its deletion leads to attenuated allergic responses . Both NDRG1 and NDRG2 are substrates of SGK1, although the precise physiological role of SGK1-mediated phosphorylation is not known . NDRG1 is phosphorylated by SGK1 at Thr328, Ser330, Thr346, Thr356, and Thr366. Phosphorylation by SGK1 primes NDRG1 for phosphorylation by GSK-3.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":45806816461080,"sku":"ABCBW06397","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_e0739fbd-d090-4641-a968-a2b0c3b44db2.png?v=1689746869","url":"https:\/\/danabiosci.com\/products\/new-product-278307","provider":"Dana Bioscience","version":"1.0","type":"link"}