{"product_id":"new-product-278306","title":"TIM3 polyclonal antibody","description":"\u003cp\u003eT cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecule that is induced following T cell activation . TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer , and tumor-infiltrating T cells that coexpress PD-1 and TIM-3 exhibit the most severe exhausted phenotype . Tumor-infiltrating dendritic cells (DCs) also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells . Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer . In addition, blockade of TIM-3 in mouse models of autoimmunity enhanced the severity of disease . Finally, binding of Galectin-9 to TIM-3 expressed by Th1 cells induces T cell death .\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse","offer_id":45806815707416,"sku":"ABCBW06396","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_9a98eaf4-4d93-4411-8653-2df6847b3d09.png?v=1689746867","url":"https:\/\/danabiosci.com\/products\/new-product-278306","provider":"Dana Bioscience","version":"1.0","type":"link"}