{"product_id":"new-product-278300","title":"Desmoplakin polyclonal antibody","description":"\u003cp\u003eDesmosomes are a class of intracellular junction that tightly link adjacent cells in mechanically stressed tissues such as the epithelium and myocardium . They derive their characteristic strength from the protein Desmoplakin, which acts as a tether by binding the cytoplasmic component of the Desmosome at it’s N-terminus while its C-terminus is anchored to the intermediate-filament cytoskeleton . This association mitigates the impact of mechanical forces on the desmosome by distributing them throughout the cytoskeleton and tissue . Desmoplakin is essential for normal desmosomal adhesion ; defects can result in pathologies that include cardiomyopathy , keratoderma , or the skin blistering disease Epidermolysis bullosa .\u003cbr\u003e\nPhospho-Desmoplakin (Ser165\/166) Antibody is directed against a site that was identified at Cell Signaling Technology (CST) using PTMScan®, our LC-MS\/MS platform for modification site discovery. Please visit PhosphoSitePlus®, a modification site knowledgebase developed and maintained by CST, at www.phosphosite.org for more information.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":45806810628376,"sku":"ABCBW06390","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_0619f051-da6e-4a2c-8740-8948108e2dd0.png?v=1689746854","url":"https:\/\/danabiosci.com\/products\/new-product-278300","provider":"Dana Bioscience","version":"1.0","type":"link"}