{"product_id":"new-product-278245","title":"COVID-19 Envelope Protein polyclonal antibody","description":"\u003cp\u003eThe cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses. The genome of SARS-CoV-2 is relatively large and encodes up to 29 open reading frames (ORFs). These include ORF1a and ORF1b (further processed into 16 non-structural proteins), 9 accessory proteins, and 4 canonical structural proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N). Envelope protein is transcribed and translated from nested subgenomic RNA of the SARS-CoV-2 genome. Despite the SARS-CoV-2 envelope protein being very small, it possesses a number of functionalities that are critical for viral assembly and release. It is also a major virulence factor, a viroporin that contributes to the host immune mediated cytokine storm. A C-terminal motif on envelope protein binds to and mislocates a number of cell tight junction proteins in lung epithelial cells which may contribute to alveolar damage and acute respiratory distress syndrome (ARDS).\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ COVID-19","offer_id":45806764720408,"sku":"ABCBW06335","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_0b9caa8e-c5d7-40cf-b3b0-e0066f922530.png?v=1689746729","url":"https:\/\/danabiosci.com\/products\/new-product-278245","provider":"Dana Bioscience","version":"1.0","type":"link"}