{"product_id":"new-product-278191","title":"PARP2 polyclonal antibody","description":"\u003cp\u003ePoly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:32028527, PubMed:32939087).\u003cbr\u003e\nMediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD+ is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30321391).\u003cbr\u003e\nSerine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087).\u003cbr\u003e\nMediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379).\u003cbr\u003e\nFollowing interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527).\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human, Rat","offer_id":45806709211416,"sku":"ABCBW06281","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_8e187151-9931-4e49-827f-57d4a58a4b6f.png?v=1689746593","url":"https:\/\/danabiosci.com\/products\/new-product-278191","provider":"Dana Bioscience","version":"1.0","type":"link"}