{"product_id":"new-product-277520","title":"Ataxin 7 Polyclonal Antibody","description":"\u003cp\u003eThe human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and\/or by disrupting nucleolar function (6).\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,","offer_id":45806470594840,"sku":"ABCBW05610","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_36891c8e-6117-421c-92be-948a49a95789.png?v=1689744943","url":"https:\/\/danabiosci.com\/products\/new-product-277520","provider":"Dana Bioscience","version":"1.0","type":"link"}