{"product_id":"new-product-276837","title":"TORC2 (Phospho-S171) polyclonal antibody","description":"\u003cp\u003eGlucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic β-cells through a glucose sensing pathway. Feeding also stimulates release of gut hormones such as glucagon-like peptide-1 (GLP-1), which further induces insulin release, inhibits glucagon release and promotes β-cell viability. CREB-dependent transcription likely plays a role in both glucose sensing and GLP-1 signaling. The protein CRTC2 (CREB-regulated transcription coactivator 2)\/TORC2 (transducer of regulated CREB activity 2) functions as a CREB co-activator and is implicated in mediating the effects of these two pathways. In quiescent cells, CRTC2\/TORC2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of CRTC2\/TORC2 and its dissociation from 14-3-3 proteins. Dephosphorylated CRTC2\/TORC2 enters the nucleus to promote CREB-dependent transcription. CRTC2\/TORC2 plays a key role in the regulation of hepatic gluconeogenic gene transcription in response to hormonal and energy signals during fasting. CRTC2\/TORC2-related proteins CRTC1\/TORC1 and CRTC3\/TORC3 also act as CREB co-activators. CRTC1\/TORC1, CRTC2\/TORC2 and CRTC3\/TORC3 associate with the HTLV Tax protein to promote Tax-dependent transcription of HTLV-1 long terminal repeats. CRTC1\/TORC1 is highly phosphorylated at Ser151 in mouse hypothalamic cells under basal conditions. When these cells are exposed to cAMP or a calcium activator, CRTC1\/TORC1 is dephosphorylated and translocates into the nucleus. CRTC1\/TORC1 is essential for energy balance and fertility.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45806063878424,"sku":"ABCBW04927","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_12815862-e59c-45a2-8954-cb086bb76b48.png?v=1689743320","url":"https:\/\/danabiosci.com\/products\/new-product-276837","provider":"Dana Bioscience","version":"1.0","type":"link"}