{"product_id":"new-product-276688","title":"TAL1 (Acetyl-K221\/K222) polyclonal antibody","description":"\u003cp\u003eActivation of TAL1 characterizes up to 60% ofcases of human T cell acute lymph oblastic leukemia,making it themost frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helixtranscription factorknown to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB\/HTF4 to a nucleotide sequence motif termed the E-box.In addition, leukemogenesisis accelerated dramatically bytransgenic coexpression of TAL1 and the catalyticsubunit ofcasein kinase IIα, a serine\/threonine protein kinase known tomodulate the activity of other βHLH transcription factors.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45805901676824,"sku":"ABCBW04778","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_27f5c210-12b3-4e58-bcb0-019f611c23a8.png?v=1689742951","url":"https:\/\/danabiosci.com\/products\/new-product-276688","provider":"Dana Bioscience","version":"1.0","type":"link"}