{"product_id":"new-product-276507","title":"ZNT8 polyclonal antibody","description":"\u003cp\u003eZinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions (such as neuroregulation) and acts as a cofactor for numerous enzymes and transcription factors. The zinc transporter (ZnT) family regulates the supply of zinc within cells, and its members commonly contain six membrane-spanning domains, a large histidine-rich intracellular loop and a C-terminal tail. ZnT-8 (zinc transporter 8), also known as SLC30A8 (solute carrier family 30 member 8), is a 369 amino acid multi-pass membrane protein that belongs to the ZnT family and is a major autoantigen in type I diabetes. Expressed specifically in pancreas islet cells, ZnT-8 functions as a zinc-efflux transporter that facilitates the accumulation of zinc in intracellular vesicles and is essential for the zinc-dependent maturation of Insulin within pancreatic cells. Multiple isoforms of ZnT-8 exist due to alternative splicing events.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Rat","offer_id":45805717520664,"sku":"ABCBW04597","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_d19eeb6b-6ad0-484e-a2f9-b6ba68422f0c.png?v=1689742533","url":"https:\/\/danabiosci.com\/products\/new-product-276507","provider":"Dana Bioscience","version":"1.0","type":"link"}