{"product_id":"new-product-276469","title":"GPR214 polyclonal antibody","description":"\u003cp\u003eSerine\/threonine-protein phosphatase 4 regulatory subunit 2, regulatory subunit of serine\/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Rat,Mouse","offer_id":45805682950424,"sku":"ABCBW04559","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_4fb19705-f5e0-499a-8b20-11749b016951.png?v=1689742445","url":"https:\/\/danabiosci.com\/products\/new-product-276469","provider":"Dana Bioscience","version":"1.0","type":"link"}