{"product_id":"new-product-276235","title":"ISG15 polyclonal antibody","description":"\u003cp\u003eUbiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G\/SPI2A, JAK1, MAPK3\/ERK1, PLCG1, EIF2AK2\/PKR, MX1\/MxA, and RIG-1. Deconjugated by USP18\/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45805447446808,"sku":"ABCBW04325","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_3d4534ef-c4a0-4f7c-bf1f-2ce8e94c091f.png?v=1689741886","url":"https:\/\/danabiosci.com\/products\/new-product-276235","provider":"Dana Bioscience","version":"1.0","type":"link"}