{"product_id":"new-product-275957","title":"GUSB polyclonal antibody","description":"\u003cp\u003eThe enzyme β-glucuronidase catalyzes the conversion of β-D-glucuronoside and water to an alcohol and D-glucuronate. Deficiency of β-glucuronidase is the cause of the human lysosomal storage disorder mucopolysaccharidosis type VII (MPS VII). Specifically, two residues appear important for catalytic activity: Glu 451 and Glu 540. Mutations at these sites affect the overall structure of the protein, which normally consists of a homotetramer with each promoter including a jelly roll barrel, an immunoglobulin constant domain and a TIM barrel. Regulation of β-glucuronidase activity may play a role in tumorigenesis and the invasiveness of a number of cancers, and is also an important factor in the development of functional prodrugs that require the cleavage of an active cytostatic by endogenous enzymes for antitumor activity.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45805156499736,"sku":"ABCBW04047","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_aec6a467-585c-4c89-981d-5121a0bfe6af.png?v=1689741171","url":"https:\/\/danabiosci.com\/products\/new-product-275957","provider":"Dana Bioscience","version":"1.0","type":"link"}