{"product_id":"new-product-275929","title":"EID1 polyclonal antibody","description":"\u003cp\u003eE1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme,\u003cbr\u003e\nbinds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue\u003cbr\u003e\nspecific transcription, and the adenovirus E1A-associated cellular p300 transcriptional\u003cbr\u003e\nco-activator protein. EID-1 inhibits cellular differentiation by blocking\u003cbr\u003e\nthe histone acetyltransferase activity of p300. EID-1 also acetylates both\u003cbr\u003e\nhistones and non-histone proteins such as NCOA3 co-activator. By acetylating\u003cbr\u003e\nhistones, EID-1 gives a specific tag for transcriptional activation. In addition\u003cbr\u003e\nto binding Rb and p300, EID-1 also binds to phosphorylated CREB protein,\u003cbr\u003e\nmediating cAMP gene regulation. EID-1 augments the activity of phosphorylated\u003cbr\u003e\nCREB and activates transcription of cAMP responsive genes as a\u003cbr\u003e\nco-activator.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":45805126877464,"sku":"ABCBW04019","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_37322e5d-37a2-40bc-b13d-d97a0c34ed6c.png?v=1689741106","url":"https:\/\/danabiosci.com\/products\/new-product-275929","provider":"Dana Bioscience","version":"1.0","type":"link"}