{"product_id":"new-product-275516","title":"ROBO1 polyclonal antibody","description":"\u003cp\u003eSpecialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior . In the vertebrate spinal cord, the insect ventral nerve cord and in C. elegans, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents, respectively . These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway . One such gatekeeper, Robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals . Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion . Non-crossing axons express high levels of Robo, whereas crossing axons express low levels of Robo before reaching the midline and high levels after they cross . Robo1 and Robo2 are two human homologs of the Drosophila protein Roundabout . Robo1 is also homologous to the C. elegans gene sax3, whereas Robo2 is homologous to the zebrafish gene astray .\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45804976079128,"sku":"ABCBW03606","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_d04ce53c-de50-445b-83ca-0c2e6b410819.png?v=1689740151","url":"https:\/\/danabiosci.com\/products\/new-product-275516","provider":"Dana Bioscience","version":"1.0","type":"link"}