{"product_id":"new-product-275368","title":"GFI1B polyclonal antibody","description":"\u003cp\u003eGrowth factor independent 1 (Gfi-1) is a transcriptional repressor that spe-cifically binds to the DNA consensus sequence TAAATCAC(A\/T)GCA. The carboxy-terminus of Gfi-1 contains six C2H2-type zinc finger motifs, and zinc fingers 3, 4 and 5 are required for the binding of Gfi-1 to its DNA binding site. Gfi-1 also contains a 20 amino acid SNAG domain which mediates transcriptional repression. It represses Bax at the mRNA and protein levels, resulting in the inhibition of cell death. Gfi-1 is expressed outside the lymphoid system in granulocytes and activated macrophages. Gfi-1B, a related protein, is a transciptional repressor primarily expressed in bone marrow and spleen. Gfi-1B is a direct repressor of the p21 promoter and the SOCS-1 and -3 promoters. The genes encoding human Gfi-1 and Gfi-1B map to chromosome 1p22 and 9q34.13, respectively.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45804954353944,"sku":"ABCBW03458","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_40eea01c-9886-4478-9f41-434fd50d2807.png?v=1689739811","url":"https:\/\/danabiosci.com\/products\/new-product-275368","provider":"Dana Bioscience","version":"1.0","type":"link"}