{"product_id":"new-product-274897","title":"LATS1 polyclonal antibody","description":"\u003cp\u003eThe Drosophila tumor suppressor protein lats (for large tumor suppressor) is a putative protein kinase that shares homology with three proteins in Neurospora and budding yeast that are involved in cell cycle and growth regulation: S. cerevisiae Dbf2 and Dbf20, and Neurospora cot-1. Mosaic screens in Drosophila have identified the lats gene as a tumor suppressor in this species. The human homolog, designated LATS1, was shown to inhibit tumor growth in lats-deficient Drosophila. Human LATS1 binds to Cdc2 in early mitosis and appears to negatively regulate the kinase activity of Cdc2. LATS1-deficient mice are highly sensitive to carcinogenic treatments and develop soft-tissue sarcomas and ovarian stromal cell tumors, indicating a role for mammalian LATS1 in tumorigenesis.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45804750995736,"sku":"ABCBW02987","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_d9fb582f-8307-4483-bcbf-36df1e9338db.png?v=1689738748","url":"https:\/\/danabiosci.com\/products\/new-product-274897","provider":"Dana Bioscience","version":"1.0","type":"link"}