{"product_id":"new-product-274895","title":"DUSP14 polyclonal antibody","description":"\u003cp\u003eThe deduced 198 amino acid MAP kinase phosphatase 6 (MKP-6), also designated MAP6 and dual-specificity phosphatase 14 (DUSP14), is homologous to other MKP family proteins in that it has a conserved, centrally located, catalytic core, but differs from traditional MKP proteins because it contains unique N- and C-terminal regions. Binding and deletion analyses have established that the interaction between the cytoplasmic tail of CD28 (a T cell antigen) and MKP-6 occurs at Tyr 200 of CD28 and is specific for both MKP-6 and CD28; however, Tyr 200 can be mutated to Phe 200 without a loss of binding ability. Functional analysis indicates that MKP-6 dephosphorylates ERK, JNK and p38 while acting as a negative regulator of CD28 signaling. MKP-6 is expressed ubiquitously, although expression is stronger in certain cell types and tissues than in others.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45804748275992,"sku":"ABCBW02985","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_2658a33a-4a24-4d81-b5c9-f0732af707d1.png?v=1689738744","url":"https:\/\/danabiosci.com\/products\/new-product-274895","provider":"Dana Bioscience","version":"1.0","type":"link"}