{"product_id":"new-product-274664","title":"Frizzled-9 polyclonal antibody","description":"\u003cp\u003eThe frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser\/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The frizzled-9 gene is located within the Williams Syndrome common deleted region at chromosomal band 7q11.23. Heterozygous deletion of the frizzled-9 gene may contribute to the Williams Syndrome phenotype. In mouse, frizzled-9 overexpression can induce the hyperphosphorylation and relocalization of Dvl-1 from the cytoplasm to the cell membrane and cytosolic β-catenin accumulation. In rat, frizzled-9 is important in Wnt\/β-catenin signaling in 293T cells. Frizzled-9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45804447596824,"sku":"ABCBW02754","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_d4ff2e8f-585a-4437-8b58-b45aa7e11324.png?v=1689738222","url":"https:\/\/danabiosci.com\/products\/new-product-274664","provider":"Dana Bioscience","version":"1.0","type":"link"}