{"product_id":"new-product-274550","title":"ERα (P124) polyclonal antibody","description":"\u003cp\u003eThe estrogen receptor-alpha (ER) is a broadly expressed transcription factor which controls a number of genes involved in cellular differentiation and proliferation. ER contains two transcriptionally active domains: the N-terminal domain (AF1) is constitutively active, while the C-terminal domain (AF-2) is hormone-dependent. ER is subject to post-translational modification, including phosphorylation of serine residues 104, 106, 118, and 167. This antibody specifically recognizes human estrogen receptor-alpha when phosphorylated at serine 167, a site which influences AF-1 dependent transcriptional activity. This phosphorylation is catalyzed by the MAPK pathway, potentially through the 90 kDa ribosomal S6 kinase (pp90rsk1). Serine 167 is also a consensus Akt substrate.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45804288213272,"sku":"ABCBW02640","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_6133dd78-27e3-4143-bc90-bde98e148a1c.png?v=1689737964","url":"https:\/\/danabiosci.com\/products\/new-product-274550","provider":"Dana Bioscience","version":"1.0","type":"link"}