{"product_id":"new-product-274091","title":"CREB (phospho-S142) polyclonal antibody","description":"\u003cp\u003eCyclic AMP Response Element Binding protein (CREB) is a basic \/ leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 \/ 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45803817861400,"sku":"ABCBW02181","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_74467c77-1e9c-4cdb-9b94-9585b71345cc.png?v=1689736834","url":"https:\/\/danabiosci.com\/products\/new-product-274091","provider":"Dana Bioscience","version":"1.0","type":"link"}