{"product_id":"new-product-273575","title":"Cerebral 1 (L310) polyclonal antibody","description":"\u003cp\u003eCerebral 1 also called hucep-1, KIAA0409 or RRP8, is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+\/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45803448369432,"sku":"ABCBW01665","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_bf480589-c48a-4cac-a1dd-5e6693fdcb53.png?v=1689735553","url":"https:\/\/danabiosci.com\/products\/new-product-273575","provider":"Dana Bioscience","version":"1.0","type":"link"}