{"product_id":"new-product-273194","title":"AIM2 (A78) polyclonal antibody","description":"\u003cp\u003eInterferon-inducible protein AIM2 (absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-γ, AIM2 is thought to act as a tumor suppressor by repressing NFκB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of α-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of caspase-1. AIM2 is present as a homodimer and is expressed highly in small intestine, testis, peripheral blood leukocytes and spleen. Defects in AIM2 are believed to be a cause of microsatellite unstable colon cancers.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45803341644056,"sku":"ABCBW01284","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_18e94277-8b37-48a6-9154-e3334cbb8dee.png?v=1689734574","url":"https:\/\/danabiosci.com\/products\/new-product-273194","provider":"Dana Bioscience","version":"1.0","type":"link"}