{"product_id":"new-product-272979","title":"TDG (K90) polyclonal antibody","description":"\u003cp\u003eIn the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G\/T mismatches. G\/T mismatch-specific Thymine DNA Glycosylase (TDG) is a nuclear protein which corrects G\/T mismatches to G\/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymine. TDG also corrects a subset of G\/U mispairs inefficiently removed by the more abundant uracil glycosylases. Retinoic acid receptors interact physically and functionally with TDG, enhancing the ability of the retinoid X receptor and the retinoid X receptor\/retinoid acid receptor complex to bind to their response elements. TDG interacts with, and is covalently modified by, the ubiquitin-like proteins SUMO-1 and SUMO-2\/3, resulting in a reduction of the DNA substrate and AP site binding affinity of TDG. This sumoylation is associated with a significant increase in enzymatic turnover in reactions with a G\/U substrate and the loss of G\/T processing activity.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45803301765400,"sku":"ABCBW01069","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_ddc36d1b-0c90-40a0-a76c-b2eb48639c0d.png?v=1689734056","url":"https:\/\/danabiosci.com\/products\/new-product-272979","provider":"Dana Bioscience","version":"1.0","type":"link"}