{"product_id":"new-product-272733","title":"CaMKIα (S173) polyclonal antibody","description":"\u003cp\u003eThe Ca2+\/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine\/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine\/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated α, β, γ and δ, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal, leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45803232297240,"sku":"ABCBW00823","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_b71f95b7-aadc-4035-80db-c574627e655a.png?v=1689733410","url":"https:\/\/danabiosci.com\/products\/new-product-272733","provider":"Dana Bioscience","version":"1.0","type":"link"}