{"product_id":"new-product-272287","title":"Neuregulin-1\/SMDF (Y4) polyclonal antibody","description":"\u003cp\u003eThe neuregulins are a family of ErbB\/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":45803141497112,"sku":"ABCBW00377","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_0aa0954d-01c9-4c72-9953-6a7958b73fc3.png?v=1689732279","url":"https:\/\/danabiosci.com\/products\/new-product-272287","provider":"Dana Bioscience","version":"1.0","type":"link"}