{"product_id":"new-product-233630","title":"TRAF6 (H154) polyclonal antibody","description":"\u003cp\u003eTumor necrosis factor receptor-associated factor 6 (TRAF6) regulates adaptive immunity, innate immunity and bone metabolism. TRAF6 is a ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IκB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub. TRAF6 is essential for activating NFκB signaling pathway in response to interleukin-1 and Toll-like receptor ligands. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination and activating NFκB signaling pathway. TRAF6 interacts with various protein kinases including IRAK1\/IRAK, SRC and PKCζ, which provides a link between distinct signaling pathways.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47665022599448,"sku":"BS3684","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_396e7bb0-40a0-4b27-9a0a-f483b59ee998.jpg?v=1707513342","url":"https:\/\/danabiosci.com\/products\/new-product-233630","provider":"Dana Bioscience","version":"1.0","type":"link"}