{"product_id":"new-product-233550","title":"Ataxin-2 (F774) polyclonal antibody","description":"\u003cp\u003eAtaxin-2, the gene product of the human spinocerebellar ataxia type 2 (SCA2\/ATXN2) gene, is a basic protein with two domains (Sm1 and Sm2) implicated in RNA splicing and protein interaction. Ataxin-2 interacts with a putative RNA-binding protein ataxin-2-binding-protein 1 (A2BP1), which is expressed in muscle and brain. Ataxin-2 is ubiquitously expressed with highest levels in the cytoplasm of Purkinje cells. Both A2BP1 and ataxin-2 are localized to the trans-Golgi network. Mice expressing ataxin-2 with polyglutamine show progressive functional deficits accompanied by loss of Purkinje cell dendritic arbor and eventually loss of Purkinje cells. In conclusion, expansion of ataxin-2 results in spinocerebellar ataxia type 2, which affects the cerebellum and other areas of the central nervous system.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47664944218392,"sku":"BS3811","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_e85da57d-981a-48e1-8aaf-548c31cfd47a.jpg?v=1707512944","url":"https:\/\/danabiosci.com\/products\/new-product-233550","provider":"Dana Bioscience","version":"1.0","type":"link"}