{"product_id":"new-product-233158","title":"TNFα-IP8 polyclonal antibody","description":"\u003cp\u003eTNFα-IP 8 (tumor necrosis factor, α-induced protein 8), also known as NFκB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFκB and TNF. The induction of TNFα-IP 8 by TNF is dependent on the activation of NFκB. TNFα-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFα-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFα-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFα-IP 8 is present as three isoforms produced by alternative splicing.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47664164241688,"sku":"BS5965","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_be3c6a2e-eb19-420e-b748-8893a1fd5415.jpg?v=1707511067","url":"https:\/\/danabiosci.com\/products\/new-product-233158","provider":"Dana Bioscience","version":"1.0","type":"link"}