{"product_id":"new-product-233116","title":"SNRPD3 polyclonal antibody","description":"\u003cp\u003eU1, U2, U4, U5, U6 and U7 are small nuclear ribonucleoproteins (snRNPs) that comprise the spliceosome in eukaryotes. Each UsnRNP contains common Sm proteins B\/B', D1, D2, D3, E, F and G. The Sm proteins pair up as D1-D2, B\/B'-D3 and E-F-G to form RNA-free hetero-oligomers in the cytoplasm. Sm proteins aid in the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex. Sm D1, D2 and D3 are present in U1, U2, U4\/5 and U5 but not U7 snRNPs in human and mouse cells. U7 snRNPs contain Lsm10, an Sm D1-like protein. Autoantibodies produced in patients suffering from systemic lupus erythematosus react predominantly with Sm B\/B', D1 and D3. The major linear epitope of these autoantibodies includes the C-terminal RG dipeptide repeats found in Sm D1 and D3.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47664153690392,"sku":"BS60048","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_06a27f3a-ebd1-4bc5-a126-c0792067274d.jpg?v=1707510859","url":"https:\/\/danabiosci.com\/products\/new-product-233116","provider":"Dana Bioscience","version":"1.0","type":"link"}